Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNOQ49)

Drug Name

1-(3,4-dichlorophenyl)-3-(3,5-dichlorophenyl)urea Drug Info

Synonyms

CHEMBL255505; 1-(3,4-dichlorophenyl)-3-(3,5-dichlorophenyl)urea; AC1LKCSZ; CBMicro_019879; AC1Q3IF4; MolPort-000-644-777; ZINC639843; CCG-8060; 1-(3,4-DICHLORO-PHENYL)-3-(3,5-DICHLORO-PHENYL)-UREA; BDBM50373332; AKOS002934710; MCULE-5556566180; BIM-0020045.P001; ST50982277; SJ000146676

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 989142
TTD Drug ID: DMNOQ49

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting P2Y purinoceptor 1 (P2RY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
adenosine diphosphate	DMFUHKP	N. A.	N. A.	Investigative	[2]
2MeSATP	DMUE0W6	Discovery agent	N.A.	Investigative	[2]
PPADS	DMWHN3T	Discovery agent	N.A.	Investigative	[2]
2MeSADP	DMGADQ1	Discovery agent	N.A.	Investigative	[3]
ATPgammaS	DMXHQIN	Discovery agent	N.A.	Investigative	[4]
2',3'-ddATP	DMOB7P6	Discovery agent	N.A.	Investigative	[4]
[35S]ADPbetaS	DMAYPTO	Discovery agent	N.A.	Investigative	[5]
MRS2298	DMZ6EGA	Discovery agent	N.A.	Investigative	[6]
MRS2500	DMNGTOY	Discovery agent	N.A.	Investigative	[7]
2,2'-pyridylisatogen tosylate	DMOQDBA	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
P2Y purinoceptor 1 (P2RY1)	TTA93TL	P2RY1_HUMAN	Inhibitor	[1]

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References

1	P2Y1 receptor antagonists as novel antithrombotic agents. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43.
2	Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
3	Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9.
4	An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 323).
6	Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002.
7	2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J Med Chem. 2003 Nov 6;46(23):4974-87.
8	2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Biochem Pharmacol. 2004 Jul 15;68(2):231-7.