Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNUSKT)

Drug Name
NSC-292213 Drug Info
Synonyms
NSC-292213; NSC292213; CHEMBL222808; AC1L8B2I; NCIStruc2_001766; NCIStruc1_001644; ZINC1565922; NCI292213; BDBM50158387; NCGC00014649; CCG-37867; NCGC00014649-02; NCGC00097752-01; NCI60_002407; 4-[(3-carboxy-4-hydroxy-1-naphthyl)(oxo)acetyl]-1-hydroxy-2-naphthoic acid; 4-[2-(3-carboxy-4-hydroxy-naphthalen-1-yl)-2-oxo-acetyl]-1-hydroxy-naphthalene-2-carboxylic acid; 4-[2-(3-carboxy-4-hydroxynaphthalen-1-yl)-2-oxoacetyl]-1-hydroxynaphthalene-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
324974
TTD Drug ID
DMNUSKT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [2]
NSC-30171 DMFBZEI Discovery agent N.A. Investigative [2]
NSC-45592 DMQ6GBX Discovery agent N.A. Investigative [2]
NSC-47729 DMRZJL1 Discovery agent N.A. Investigative [2]
NSC-26699 DM4RPBJ Discovery agent N.A. Investigative [2]
NSC-37173 DMZFULS Discovery agent N.A. Investigative [2]
NSC-58046 DMI6WA7 Discovery agent N.A. Investigative [2]
NSC-37031 DMLY6WX Discovery agent N.A. Investigative [2]
NSC-324572 DMN50OT Discovery agent N.A. Investigative [2]
NSC-126445 DMHGIB1 Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-661755 DMDJT7U N. A. N. A. Terminated [1]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [3]
MANGOSTIN DMYQGDV Discovery agent N.A. Investigative [1]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [4]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [3]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT Discovery agent N.A. Investigative [4]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ Discovery agent N.A. Investigative [5]
Jaspic acid DMOF0TB Discovery agent N.A. Investigative [4]
DYSIDENIN DMIZQTX Discovery agent N.A. Investigative [1]
Polybrominated diphenyl ether derivative DMG7K84 Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 12-lipoxygenase (12-LOX) TT12ABZ LOX12_HUMAN Inhibitor [1]
Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) TT9NVXQ PUR9_HUMAN Inhibitor [2]

References

1 Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
2 Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90.
3 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
4 Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
5 Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.