Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNX6CE)

Drug Name

1-(2,2'-bithiophen-5-yl)methanamine Drug Info

Synonyms

4380-96-5; [2,2'-Bithiophen]-5-ylmethanamine; 2,2'-bithiophene-5-methylamine; 2,2'-bithiophen-5-ylmethanamine; [2,2'-Bithiophene]-5-methanamine; 1-(2,2'-bithiophen-5-yl)methanamine; 2,2-Bithiophene-5-methylamine; CHEMBL538940; (5-(2-thienyl)-2-thienyl)methylamine; [5-(Thiophen-2-Yl)Thiophen-2-Yl]Methanamine; SDCCGMLS-0065983.P001; AC1MCQYM; SCHEMBL2690127; CTK1D7717; DTXSID50380066; MolPort-000-142-515; FHYTVXBZSXZMGD-UHFFFAOYSA-N; ZINC158800; 2,2''-bithiophen-5-ylmethanamine; AC1Q5409; QC-966; SBB091920; BDBM50294164

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2776424
CAS Number: CAS 4380-96-5
TTD Drug ID: DMNX6CE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Leukotriene A-4 hydrolase (LTA4H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bestatin	DM8L9D4	Acute myeloid leukaemia	2A60	Approved	[2]
LYS006	DMI17QR	Ulcerative colitis	DD71	Phase 2	[3]
Acebilustat	DM19UTO	Chronic blistering skin disorder	ME63.3	Phase 1	[4]
DG051	DM3I0GS	Myocardial infarction	BA41-BA43	Discontinued in Phase 2	[5]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[6]
JNJ-10392980	DMZH0K8	Discovery agent	N.A.	Investigative	[7]
4-(2-amino-1,3-thiazol-4-yl)phenol	DMH5CAQ	Discovery agent	N.A.	Investigative	[1]
2-(4-phenoxyphenoxy)ethanamine	DM7TBUJ	Discovery agent	N.A.	Investigative	[8]
3-(Benzyloxy)Pyridin-2-Amine	DM35VEI	Discovery agent	N.A.	Investigative	[6]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene A-4 hydrolase (LTA4H)	TTXZEAJ	LKHA4_HUMAN	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
3	Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A(4) Hydrolase. J Med Chem. 2021 Feb 25;64(4):1889-1903.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.
8	Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52.
9	Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.