Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNX9FC)

Drug Name

Aminomethylcyclohexane Drug Info

Synonyms

Cyclohexanemethylamine; Cyclohexylmethanamine; 3218-02-8; Aminomethylcyclohexane; (Aminomethyl)cyclohexane; Cyclohexanemethanamine; 1-Cyclohexylmethanamine; Hexahydrobenzylamine; 1-cyclohexylmethylamine; 4-aminomethylcyclohexane; C-Cyclohexyl-methylamine; CHEMBL1049; DECARBOXYLATED DERIVATIVE; AVKNGPAMCBSNSO-UHFFFAOYSA-N; EINECS 221-741-8; NSC 172991; BRN 0635751; 1tng; Cyclohexanemethyamine; cyclohexylmethyl amine; cyclohexanemethylamirie; CyclohexYl-Methanamine; cyclohexanemethyl amine; cyclohexane methylamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 76688
CAS Number: CAS 3218-02-8
TTD Drug ID: DMNX9FC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[2]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[3]
RWJ-3981	DMBVLCQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
RWJ-140998	DMP7SI9	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
EUPATORIOPICRIN	DM068CY	Discovery agent	N.A.	Investigative	[5]
CNICIN	DMEVM0J	Discovery agent	N.A.	Investigative	[5]
L-Iso-Aspartate	DM26AB4	Discovery agent	N.A.	Investigative	[1]
Cyclohexylammonium Ion	DMYQH2N	Discovery agent	N.A.	Investigative	[1]
CYNAROPICRIN	DMG0PHU	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)	TTICX3S	MURA_ECOLI	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
4	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
5	Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.