Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNYQL9)

• Drug Name: DYSIDINE Drug Info
• Synonyms: Dysidine; CHEBI:65816; 2-[(4-hydroxy-3,6-dioxo-5-{[(1R,2R,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-2-yl]methyl}cyclohexa-1,4-dien-1-yl)amino]ethanesulfonic acid; dicidin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10321583
  ChEBI ID: CHEBI:65816
  TTD Drug ID: DMNYQL9

Molecule-Related Drug Atlas

Drug(s) Targeting Group IIA phospholipase A2 (GIIA sPLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KH064	DMR1NYF	Breast cancer	2C60-2C65	Clinical trial	[3]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[4]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[4]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[5]
2-(4-phenoxyphenoxy)ethanamine	DM7TBUJ	Discovery agent	N.A.	Investigative	[6]
CACOSPONGIONOLIDE	DMIPJUS	Discovery agent	N.A.	Investigative	[7]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[4]
Cacospongionolide E	DM2DYAV	Discovery agent	N.A.	Investigative	[7]
N-Tridecanoic Acid	DMNZ37C	Discovery agent	N.A.	Investigative	[5]
CACOSPONGIONOLIDE B	DMCSXNW	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[8]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[9]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[10]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[11]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[12]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[13]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[4]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[4]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Group IIA phospholipase A2 (GIIA sPLA2)	TTO8QRU	PA2GA_HUMAN	Inhibitor	[2]
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[1]

References

• [1] A novel sesquiterpene quinone from Hainan sponge Dysidea villosa. Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2.
• [2] New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.
• [3] D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [6] Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.
• [7] A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.
• [8] Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
• [9] Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
• [10] Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
• [11] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
• [12] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
• [13] 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.