Details of the Drug

General Information of Drug (ID: DMP8VDT)

Drug Name

Elaidoylamide

Synonyms

Oleamide; Oleic acid amide; 301-02-0; Oleylamide; Oleyl amide; Adogen 73; Crodamide O; Slip-eze; Armoslip CP; Crodamide OR; cis-9,10-Octadecenoamide; (Z)-9-OCTADECENAMIDE; (9Z)-octadec-9-enamide; 9-Octadecenamide, (Z)-; (Z)-octadec-9-enamide; ELAIDOYLAMIDE; 9Z-octadecenamide; 9,10-octadecenamide; Unislip 1759; Kemamide O; Petrac Slip-Eze; UNII-7L25QK8BWO; Armid O; Amide O; trans-9,10-octadecenoamide; cis-9-Octadecenamide; 9-Octadecenamide, (9Z)-; 14C-labeled oleamide; Diamide O 200; HSDB 5560; (9E)-OCTADEC-9-ENAMIDE; oleamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 2

Molecular Weight (mw)

281.5

Logarithm of the Partition Coefficient (xlogp)

6.6

Rotatable Bond Count (rotbonds)

15

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

1

Chemical Identifiers

Formula: C18H35NO
IUPAC Name: (Z)-octadec-9-enamide
Canonical SMILES: CCCCCCCC/C=C\\CCCCCCCC(=O)N
InChI: InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-
InChIKey: FATBGEAMYMYZAF-KTKRTIGZSA-N

Cross-matching ID

PubChem CID: 5283387
ChEBI ID: CHEBI:116314
CAS Number: 301-02-0
TTD ID: D03AHJ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Modulator (allosteric modulator)	[2]
Group IIA phospholipase A2 (GIIA sPLA2)	TTO8QRU	PA2GA_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Choline O-acetyltransferase (CHAT)	OTEJWQ45	CLAT_HUMAN	Gene/Protein Processing	[3]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Protein Interaction/Cellular Processes	[4]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Gene/Protein Processing	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 7 receptor (HTR7)	DTT	HTR7	9.79E-01	-0.08	-0.32

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem Pharmacol. 1999 Dec 1;58(11):1807-13.
3	Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem. 2003 Jun;67(6):1284-91.
4	Gap junction communications influence upon fibroblast synthesis of Type I collagen and fibronectin. J Cell Biochem. 2006 Jul 1;98(4):735-43. doi: 10.1002/jcb.20852.
5	Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells. Toxicol Appl Pharmacol. 2018 Feb 1;340:67-76. doi: 10.1016/j.taap.2017.12.014. Epub 2017 Dec 27.