Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNZG8T)

Drug Name

PF-821385 Drug Info

Synonyms

PF-348089; Gp120 inhibitor (HIV), Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Preclinical	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fostemsavir	DM50ILT	Human immunodeficiency virus infection	1C62	Approved	[3]
AIDSVAX	DMS2WV3	Human immunodeficiency virus infection	1C62	Phase 3	[4]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[5]
BMS-488043	DMRPU10	Human immunodeficiency virus infection	1C62	Discontinued in Phase 2	[6]
Pro 542	DMLOGR3	Human immunodeficiency virus infection	1C62	Discontinued in Phase 2	[7]
CD4 red blood cell electroinsertion	DMIV82T	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120)	TTBYP1X	ENV_HV1H2	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023943)
2	Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution. PLoS Pathog. 2013 February; 9(2): e1003184.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2020
4	HIV gp120 vaccine - VaxGen: AIDSVAX, AIDSVAX B/B, AIDSVAX B/E, HIV gp120 vaccine - Genentech, HIV gp120 vaccine AIDSVAX - VaxGen, HIV vaccine AIDSVAX - VaxGen. Drugs R D. 2003;4(4):249-53.
5	An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.
6	The investigations on HIV-1 gp120 bound with BMS-488043 by using docking and molecular dynamics simulations.J Mol Model.2013 Feb;19(2):905-17.
7	Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother. 2004 Feb;48(2):423-9.
8	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120. J Acquir Immune Defic Syndr. 1990;3(11):1041-5.