Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNZSC1)

Drug Name

Candicidin Drug Info

Synonyms

(23E,25E,27E,29E,31E,33E,35E)-22-(4-amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-10,12,14,18,20-pentahydroxy-37-methyl-2,4,8,16-tetraoxo-1-oxacyclooctatriaconta-23,25,27,29,31,33,35-heptaene-19-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 10079874
ChEBI ID: CHEBI:3349
CAS Number: CAS 1403-17-4
TTD Drug ID: DMNZSC1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Fungal Cell membrane ergosterol (Fung CME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[3]
Nystatin	DM63QS9	Cutaneous candidiasis	1F23.14	Approved	[4]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Cell membrane ergosterol (Fung CME)	TTQKWA4	NOUNIPROTAC	Modulator	[2]

------------------------------------------------------------------------------------

References

1	Drug information of Candicidin, 2008. eduDrugs.
2	Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans
3	Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. Biochim Biophys Acta. 2002 Dec 23;1567(1-2):63-78.
4	Cholesterol and Ergosterol Influence Nystatin Surface Aggregation: Relation to Pore Formation