Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTQKWA4)

DTT Name Fungal Cell membrane ergosterol (Fung CME)
Gene Name Fung CME
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T32862

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [1]
Candicidin DMNZSC1 Bacterial infection 1A00-1C4Z Approved [2]
Nystatin DM63QS9 Cutaneous candidiasis 1F23.14 Approved [3]
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References

1 Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. Biochim Biophys Acta. 2002 Dec 23;1567(1-2):63-78.
2 Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans
3 Cholesterol and Ergosterol Influence Nystatin Surface Aggregation: Relation to Pore Formation