Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO1Z5Q)

Drug Name

L-lactic acid Drug Info

Synonyms

L-lactate; lactate; (S)-lactate; (S)-lactic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting G protein coupled receptor 81 (HCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-lactic acid	DMBNFQ8	Discovery agent	N.A.	Investigative	[4]
3,5-dihydroxybenzoic acid	DM04N7I	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G protein coupled receptor 81 (HCAR1)	TTVK4ZO	HCAR1_HUMAN	Agonist	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Lactate dehydrogenase C (LDHC)^{Main DME}	DEQG7F9	LDHC_HUMAN	Substrate	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2932).
2	Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
3	Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int. 2015 Feb 15;15:19.
4	Role of GPR81 in lactate-mediated reduction of adipose lipolysis. Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91.
5	3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012 Jun;341(3):794-801.