Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO5JS3)

Drug Name

GSK3389404 Drug Info

Synonyms

IONIS-HBV-LRX

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B	1E51	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK3228836	DMPBK8N	Hepatitis B	1E51	Phase 2	[3]
RG6346	DMOWYKS	Hepatitis B virus infection	1E51.0	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA)	TTSJVOI	HBSAG_HBVD3	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03020745) A Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3389404 in Chronic Hepatitis B (CHB) Subjects. U.S. National Institutes of Health.
2	A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Aug;8(6):790-801.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline.
4	Clinical pipeline report, company report or official report of Dicerna Pharmaceuticals.