Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO648T)

Drug Name

Carbenoxolone Drug Info

Synonyms

carbenoxolone; 5697-56-3; UNII-MM6384NG73; OBZHEBDUNPOCJG-WBXJDKIVSA-N; MM6384NG73; Carbenoxolone [INN:BAN]; Carbenoxolonum [INN-Latin]; Carbenoxolona [INN-Spanish]; Carbenoxolona; Carbenoxolonum; EINECS 227-174-2; CBO; (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(4-hydroxy-4-oxobutanoyl)oxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid; 3beta-Hydroxy-11-oxoolean-12-en-30-saeure hydogensuccinat; 3beta-(3-Carboxypropionyloxy)-11-oxo-olean-12-en-30-saeure

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 636403
CAS Number: CAS 5697-56-3
TTD Drug ID: DMO648T

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[3]
BVT.2733	DM6RUKX	Lupus	4A40	Phase 3	[4]
INCB13739	DMLQ3PO	Type-2 diabetes	5A11	Phase 2a	[5]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[6]
JTT-654	DM50M2R	Type-2 diabetes	5A11	Phase 2	[7]
RG-4929	DMT4QRD	Metabolic disorder	5C50-5D2Z	Phase 2	[7]
BMS-770767	DMTVGY7	Hypercholesterolaemia	5C80.0	Phase 2	[7]
UE-2343	DMIERPK	Alzheimer disease	8A20	Phase 2	[8]
AZD-4017	DML9M5S	Ocular hypertension	9C61.01	Phase 2	[7]
Xanamem	DM580GT	Alzheimer disease	8A20	Phase 1/2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4151).
2	Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):248-52.
3	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009 Aug 1;17(15):5722-32.
4	Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62.
5	Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008.
6	11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
7	New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Selection and early clinical evaluation of the brain-penetrant 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor UE2343 (Xanamem?). Br J Pharmacol. 2017 Mar;174(5):396-408.