Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOBEL9)

Drug Name

7,8,3',4'-tetrahydroxyflavone Drug Info

Synonyms

7,8,3',4'-tetrahydroxyflavone; 3440-24-2; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4-one; 3',4',7,8-Tetrahydroxyflavone; CHEMBL222541; ARYCMKPCDNHQCL-UHFFFAOYSA-N; ST059620; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxychromen-4-one; AC1LEMTC; AC1Q6AJ1; SCHEMBL35318; CTK4H2335; ZINC57844; DTXSID20350973; 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4h-chromen-4-on; CHEBI:125596; 7,8,3'',4''-tetrahydroxyflavone; BDBM50157547; AKOS024283046; ACM3440242; MCULE-5496936655; ZB002260; DB-048618; FT-0614178; C-57754

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 688798
ChEBI ID: CHEBI:125596
CAS Number: CAS 3440-24-2
TTD Drug ID: DMOBEL9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting TERT messenger RNA (TERT mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[2]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[2]
2,7-Bis(acetamido)anthraquinone	DM2EPM4	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(cyclohexanecarbonamido)anthraquinone	DMTPZ8D	Discovery agent	N.A.	Investigative	[3]
2,7-Bis[2-(isopropylamino)acetamido]anthraquinone	DMRQGWX	Discovery agent	N.A.	Investigative	[3]
NSC-745884	DM8W0J3	Discovery agent	N.A.	Investigative	[4]
2,7-Bis[3-(piperidino)propionamido]anthraquinone	DMET693	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(cyclopropanecarbonamido)anthraquinone	DMY3V2B	Discovery agent	N.A.	Investigative	[3]
2,7-Bis(phenylacetamido)anthraquinone	DMEVIBT	Discovery agent	N.A.	Investigative	[3]
NSC-745887	DMG9BWY	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TERT messenger RNA (TERT mRNA)	TTQY2EJ	TERT_HUMAN	Inhibitor	[1]

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References

1	Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75.
2	Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
3	Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86.
4	Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28.