Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOFDVE)

Drug Name

2-tosylanthracene-1,4-diol Drug Info

Synonyms

CHEMBL451059; 2-tosylanthracene-1,4-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[2]
2-(4-Bromo-3-phenoxy-benzoylamino)-benzoic acid	DMY8GZP	Discovery agent	N.A.	Investigative	[3]
2-(4-Fluoro-3-phenoxy-benzoylamino)-benzoic acid	DMGLEX5	Discovery agent	N.A.	Investigative	[3]
2-Hydroxy-6-(3-phenoxy-benzoylamino)-benzoic acid	DMB3Y8H	Discovery agent	N.A.	Investigative	[3]
2-Tosylnaphthalene-1,4-diol	DM5FHO4	Discovery agent	N.A.	Investigative	[1]
2-(p-tolylthio)naphthalene-1,4-dione	DMON1A5	Discovery agent	N.A.	Investigative	[1]
2-tosylnaphthalene	DM2OUG0	Discovery agent	N.A.	Investigative	[1]
2-(4-propylphenylsulfonyl)naphthalene-1,4-diol	DMXC20R	Discovery agent	N.A.	Investigative	[1]
2-(4-chlorophenylsulfonyl)naphthalene-1,4-diol	DMJORCV	Discovery agent	N.A.	Investigative	[1]
2-[3-(Pyridin-4-yloxy)-benzoylamino]-benzoic acid	DM5ETL9	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH)	TTRVTMX	FABH_ECOLI	Inhibitor	[1]

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References

1	Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5.
2	The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
3	Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609.