General Information of Drug (ID: DMOH45T)

Drug Name
PMID24556381C10l Drug Info
Synonyms GTPL8603; BDBM50449284
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
76318115
TTD Drug ID
DMOH45T

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bucelipase alfa DM50SNX Exocrine pancreatic insufficiency DC35.1 Phase 3 [2]
Taurocholic Acid DM2LZ8F Type-2 diabetes 5A11 Phase 1/2 [3]
CVT-1 DMPWZCI Hypercholesterolaemia 5C80.0 Terminated [4]
PMID24556381C10f DMK6GAU Discovery agent N.A. Investigative [1]
TgBSSL DMBFX7S Pancreatic malfunction DC30-DC3Z Investigative [5]
Drug(s) Targeting Neutrophil elastase (NE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sivelestat sodium hydrate DMOSJD0 Acute lung injury NB32.3 Phase 4 [6]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [7]
Sivelestat DM6BZCV Crohn disease DD70 Phase 3 [8]
Tiprelestat DM1SB94 Myocardial infarction BA41-BA43 Phase 2 [9]
AZD9668 DMB87M3 Bronchiectasis CA24 Phase 2 [10]
L-694,458 DMA0DSJ Cystic fibrosis CA25 Phase 2 [11]
BAY 85-8501 DMCPUKG Bronchiectasis CA24 Phase 2 [12]
DX-890 DMBFZET Acute lung injury NB32.3 Phase 2 [6]
POL-6014 DM9B68S Cystic fibrosis CA25 Phase 1 [13]
AZD-9819 DMWYHXG Chronic obstructive pulmonary disease CA22 Phase 1 [14]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bile-salt-activated lipase (CEL) TTTRNQW CEL_HUMAN Inhibitor [1]
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Inhibitor [1]

References

1 Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9.
2 ClinicalTrials.gov (NCT00743483) Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency. U.S. National Institutes of Health.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovasc Drugs Ther. 1999 Sep;13(5):449-54.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2872).
6 Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77.
7 Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett. 2010 Jan 15;20(2):513-5.
8 Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. Inflamm Res. 2009 Apr;58(4):198-203.
9 Company report (Proteo Biotech AG)
10 Clinical pipeline report, company report or official report of AstraZeneca (2009).
11 Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.
12 Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 5-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.
13 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).
14 Lipid Peroxide-Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples. Drug Metab Dispos. 2015 Oct;43(10):1441-9.