Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOJ917)

Drug Name

Cinchoninic acid Drug Info

Synonyms

Quinoline-4-carboxylic acid; 486-74-8; 4-Quinolinecarboxylic acid; CINCHONINIC ACID; 4-Carboxyquinoline; Cinchonic acid; USAF D-2; NSC 13138; EINECS 207-640-1; MFCD00006782; Quinoline-4-Carboxylicacid; BRN 0005224; 4-QuinolinecarboxylicAcid; Cinchoninsaure; PubChem5843; Chinolin-4-carbonsaeure; AC1L1USE; Maybridge1_002367; quinoline4-carboxylic acid; 4-quinoline carboxylic acid; ACMC-1AM77; WLN: T66 BNJ EVQ; Oprea1_466681; KSC171Q1F; 5-22-03-00204 (Beilstein Handbook Reference); SCHEMBL228713; DivK1c_001119; AC1Q72O9; CHEBI:18311

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10243
ChEBI ID: CHEBI:18311
CAS Number: CAS 486-74-8
TTD Drug ID: DMOJ917

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[2]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[3]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[4]
Atovaquone	DMY4UMW	Fungal infection	1F29-1F2F	Approved	[5]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[6]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[6]
Orotate	DMMB29S	Discovery agent	N.A.	Investigative	[7]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[6]
1,4-Naphthoquinone	DMTCMH7	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)	TT3PQ2Y	PYRD_PLAF7	Inhibitor	[1]

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References

1	Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76.
2	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
3	Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur J Biochem. 1999 Dec;266(3):1184-91.
4	Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8.
5	Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci. 2004 Apr;13(4):1031-42.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.