Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMONK0F)

Drug Name

GNF-PF-2272 Drug Info

Synonyms

3-Methyltoxoflavin; GNF-Pf-2272; MLS000528498; SMR000121073; 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione; BAS 00444306; 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione; 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione; SR-01000322764; methyltoxoflavin; CPXHNWKHOFNPDO-UHFFFAOYSA-N; 3-methyl toxoflavin; AC1LA2XZ; 32502-62-8; cid_460747; SCHEMBL2180986; CHEMBL601757; BDBM34671; CHEBI:95315; KUC104460N; HMS2304H14; STK397047; KSC-1-228; MCULE-2510138695; NCGC00093522-02; NCGC00093522-01; HY-111117

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 460747
ChEBI ID: CHEBI:95315
TTD Drug ID: DMONK0F

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Candida Mannose-6-phosphate isomerase (Candi PMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfacetamide	DMZ6VEY	Acne vulgaris	ED80	Approved	[2]
Sulfoxone	DMAYX6P	Dermatitis herpetiformis	EB44	Approved	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[3]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[3]
GNF-PF-5134	DM7850H	Discovery agent	N.A.	Investigative	[1]
NSC-66209	DMQ0S4B	Discovery agent	N.A.	Investigative	[1]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[1]
SIS-3	DMWBCTA	Renal fibrosis	GC01	Preclinical	[4]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Candida Mannose-6-phosphate isomerase (Candi PMI1)	TT915ZD	MPI_CANAL	Inhibitor	[1]
Mothers against decapentaplegic homolog 3 (SMAD3)	TTHQZV7	SMAD3_HUMAN	Inhibitor	[1]

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References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
2	Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.