Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMONWJ4)

Drug Name

Imetelstat Drug Info

Synonyms

Motesanib diphosphate; 857876-30-3; Motesanib (Diphosphate); Motesanib Diphosphate (AMG-706); UNII-T6Q3060U91; Motesanib diphosphate [USAN]; T6Q3060U91; Motesanib diphosphate (USAN); AMG-706 diphosphate; Motesanib phosphate (JAN); bis(phosphoric acid); Motesanib Diphosphate/AMG-706; CHEMBL2107357; DTXSID30235080; C22H29N5O9P2; MolPort-016-633-170; HMS3654K07; AOB87339; ABP000867; AKOS026750408; CS-0193; API0006359; AN-5306; SB16584; RL05311; AS-17019; HY-10229; SW218300-2; FT-0672543; X7466; D08947; W-5527; A841448

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 2/3	[1]
Breast cancer	2C60-2C65	Phase 2	[2]
Essential thrombocythemia	3B63.1Z	Phase 2	[2]
Multiple myeloma	2A83	Phase 2	[2]
Myelofibrosis	2A20.2	Phase 2	[1]
Non-small-cell lung cancer	2C25.Y	Phase 2	[2]

Cross-matching ID

PubChem CID: 71587831
CAS Number: CAS 868169-64-6
TTD Drug ID: DMONWJ4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[3]
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[4]
VM1500A	DM9YSSY	Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[5]
Dendritic cell vaccine	DML4PMG	Ovarian cancer	2C73	Phase 2	[6]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[7]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[8]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[9]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[10]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[11]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Telomerase reverse transcriptase (TERT)	TTUJFD0	TERT_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT02426086) Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor. U.S. National Institutes of Health.
3	Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103.
4	Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer. 2006 Dec 4;95(11):1474-82.
5	Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida(?)) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1056-1060.
6	In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8.
7	Targeting telomerase-expressing cancer cells. J Cell Mol Med. 2011 Jul;15(7):1433-42.
8	Clinical pipeline report, company report or official report of Vaxon-biotech.
9	Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12.
10	Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
11	Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):285-92.
12	National Cancer Institute Drug Dictionary (drug id 672554).