Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOTPJD)

Drug Name
Rockout Drug Info
Synonyms
3-(Pyridin-4-yl)-1H-indole; 3-(4-Pyridyl)indole; rockout; 3-(pyridin-4-yl)-1H-indole; 7272-84-6; 3-Pyridin-4-yl-1H-indole; 3-(4-Pyridyl)-1H-indole; Rho Kinase Inhibitor III, Rockout; 3-(4-Pyridinyl)-1H-indole; CHEMBL380071; 1H-indole, 3-(4-pyridinyl)-; 3-(4-Pyridyl); Rho kinase inhibitor III; ChemDiv2_000332; AC1LD92F; Oprea1_292323; Oprea1_060403; CBDivE_015772; MLS000029246; SCHEMBL238277; GTPL6032; cid_644354; ZINC80555; CHEBI:93984; DTXSID90349379; 3-(PYRIDIN-4-YL)INDOLE; MolPort-001-899-519; HMS1369P02; HMS3229K13; HMS2280K08; STL331403; IN1125; BDBM50182878; rockout
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
644354
ChEBI ID
CHEBI:93984
CAS Number
CAS 7272-84-6
TTD Drug ID
DMOTPJD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [3]
Urea and carbamate bioisostere derivative 1 DMEQFXZ N. A. N. A. Patented [4]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [5]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [5]
Mycophenolic hydroxamic acid DM4YRAH Discovery agent N.A. Investigative [6]
Tiazofurin adenine dinucleotide DMEFVPH Discovery agent N.A. Investigative [7]
Mycophenolic bis(sulfonamide) DMUQP3J Discovery agent N.A. Investigative [8]
6-Chloropurine Riboside, 5'-Monophosphate DMWB43U Discovery agent N.A. Investigative [5]
1-methyl-1H-indole-3-carboxamide DMUKAH6 Discovery agent N.A. Investigative [9]
6-phenyl-3-(pyridin-4-yl)-1H-indole DM3UBR5 Discovery agent N.A. Investigative [2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) TTTB4UP IMDH2_HUMAN Inhibitor [2]

References

1 Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem. 1996 Aug 23;271(34):20246-9.
2 Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42.
3 Clinical pipeline report, company report or official report of Roche (2009).
4 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
5 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6 Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
7 Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
8 Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
9 Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.