Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOWYKS)

Drug Name

RG6346 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B virus infection	1E51.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK3228836	DMPBK8N	Hepatitis B	1E51	Phase 2	[2]
GSK3389404	DMO5JS3	Hepatitis B	1E51	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA)	TTSJVOI	HBSAG_HBVD3	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of Dicerna Pharmaceuticals.
2	Clinical pipeline report, company report or official report of GlaxoSmithKline.
3	A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Aug;8(6):790-801.