Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP7SI9)

Drug Name

RWJ-140998 Drug Info

Synonyms

4-hydroxy-1-methyl-7,8,9,10-tetrahydro-6H-[1,3]thiazocino[2,3-f]purin-2(1H)-one; RWJ-140998; AC1LIVUI; Oprea1_483450; MolPort-005-971-769; MolPort-002-544-111; ZINC496244; STK643127; AKOS005574570; AKOS030506897; MCULE-9461774198; 1-methyl-7,8,9,10-tetrahydro-6H-purino[8,7-b][1,3]thiazocine-2,4-dione; 1-methyl-7,8,9,10-tetrahydro-1H-[1,3]thiazocino[2,3-f]purine-2,4(3H,6H)-dione

Indication

Disease Entry	ICD 11	Status	REF
Gram-positive bacterial infection	1B74-1G40	Investigative	[1]

Cross-matching ID

PubChem CID: 912224
TTD Drug ID: DMP7SI9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[2]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[3]
RWJ-3981	DMBVLCQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[1]
Aminomethylcyclohexane	DMNX9FC	Discovery agent	N.A.	Investigative	[4]
EUPATORIOPICRIN	DM068CY	Discovery agent	N.A.	Investigative	[5]
CNICIN	DMEVM0J	Discovery agent	N.A.	Investigative	[5]
L-Iso-Aspartate	DM26AB4	Discovery agent	N.A.	Investigative	[4]
Cyclohexylammonium Ion	DMYQH2N	Discovery agent	N.A.	Investigative	[4]
CYNAROPICRIN	DMG0PHU	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)	TTICX3S	MURA_ECOLI	Inhibitor	[1]

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References

1	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
2	Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.