Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP86R3)

Drug Name

1,3-bis(1,3-benzothiazol-2-ylthio)acetone Drug Info

Synonyms

1,3-bis(1,3-benzothiazol-2-ylsulfanyl)propan-2-one; MLS000533100; AC1LOHTK; 1,3-bis(1,3-benzothiazol-2-ylthio)acetone; CBMicro_026328; CHEMBL1526448; MolPort-002-158-967; HMS2496A11; ZINC1029672; 1,3-dibenzothiazol-2-ylthioacetone; STK733322; AKOS001750462; MCULE-2850305009; ST006263; SMR000140538; BIM-0026345.P001; 1,3-bis(benzo[d]thiazol-2-ylthio)propan-2-one; SR-01000535355; SR-01000535355-1; 1,3-bis(1,3-benzothiazol-2-ylsulfanyl)propane-2-one; F1563-0006; A2660/0113409

Indication

Disease Entry	ICD 11	Status	REF
Glioma	2A00.0	Investigative	[1]
Melanoma	2C30	Investigative	[1]

Cross-matching ID

PubChem CID: 1240423
TTD Drug ID: DMP86R3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting AP endonuclease 1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APX3330	DMU6NBO	Diabetic retinopathy	9B71.0	Phase 2	[2]
APX-3330	DMXIMQT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
5-fluoro-1H-indole-2-carboxylic acid	DM9U1HV	Glioma	2A00.0	Investigative	[1]
3-benzofuran-2-yl-2-benzothiazol-2-yl-3-oxo-propanenitrile	DMWLIK1	Glioma	2A00.0	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
AP endonuclease 1 (APEX1)	TTHGL48	APEX1_HUMAN	Inhibitor	[1]

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References

1	Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63.
2	Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. NPJ Precis Oncol. 2017;1:19.
3	Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res. 2011 Jan;51(1):93-100.