Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPCRUT)

Drug Name

Teglicar Drug Info

Synonyms

Reversible palmitoyltransferase inhibitor; ST-1326

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Carnitine acyltransferase (CRAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LXR-015-2	DMXYDJR	Ischemia	8B10-8B11	Terminated	[3]
Coenzyme A	DM1I8LU	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carnitine acyltransferase (CRAT)	TTC8M31	CACP_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017026)
2	Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis. Diabetes. 2011 February; 60(2): 644-651.
3	EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Brain Res. 2006 Nov 6;1118(1):168-75.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.