Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPH916)

Drug Name

Olutasidenib Drug Info

Synonyms

FT-2102; NEQYWYXGTJDAKR-JTQLQIEISA-N; Olutasidenib; UNII-0T4IMT8S5Z; 0T4IMT8S5Z; (S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; Olutasidenib [USAN]; SCHEMBL17603134; HY-114226; CS-0080183; 5-(((1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-(((1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro-1-methyl-6-oxo-; 1887014-12-1

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Approved	[1]
Glioma	2A00.0	Phase 1/2	[2]
Myelodysplastic syndrome	2A37	Phase 1	[3]

Cross-matching ID

PubChem CID: 118955396
CAS Number: CAS 1887014-12-1
TTD Drug ID: DMPH916

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Oxalosuccinate decarboxylase (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivosidenib	DM8S6T7	Acute myeloid leukaemia	2A60	Approved	[4]
IDH305	DMNWPMO	Advanced malignancy	2A00-2F9Z	Phase 1	[3]
LY3410738	DMFU0H5	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxalosuccinate decarboxylase (IDH1)	TTV2A1R	IDHC_HUMAN	Inhibitor	[1]

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References

1	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215814.
2	ClinicalTrials.gov (NCT03684811) A Study of FT 2102 in Participants With Advanced Solid Tumors and Gliomas With an IDH1 Mutation. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5	LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML). Cancer Res 2020;80(16 Suppl):Abstract nr 6417.