General Information of Drug (ID: DMQA7ZS)

Drug Name
Trisnorsqualene difluoromethylidene Drug Info
Synonyms Trisnorsqualene difluoromethylidene; CHEMBL457687; SCHEMBL9152042; SCHEMBL9152035
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15119643
TTD Drug ID
DMQA7ZS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Naftifine DMHVBG1 Dermatomycosis EA60 Approved [2]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [3]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [1]
FR-194738 DMNACIV Hypercholesterolaemia 5C80.0 Terminated [4]
SDZ-87-469 DMBY6CQ Coronary artery disease BA80 Terminated [3]
NB-598 DMJVTQN N. A. N. A. Terminated [5]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [1]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose DMTK650 Discovery agent N.A. Investigative [1]
Pedunculagin DMKLRCX Discovery agent N.A. Investigative [1]
CORILAGIN DMAC698 Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Squalene monooxygenase (SQLE) TTE14XG ERG1_HUMAN Inhibitor [1]

References

1 Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4.
2 Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7.
3 Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81.
4 Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.
5 Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50.