Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQFPI1)

Drug Name

mRNA-3927 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Propionic acidemia	5C50.E0	Phase 2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Propionyl-CoA carboxylase alpha chain, mitochondrial messenger RNA (PCCA mRNA)	TT1JDE3	PCCA_HUMAN	Not Available	[2]
Propionyl-CoA carboxylase beta chain, mitochondrial messenger RNA (PCCB mRNA)	TT5LURU	PCCB_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT05130437) A Phase 1/2, Global, Open-Label, Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study. U.S.National Institutes of Health.
2	Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia. Nucleic Acid Ther. 2023 Apr;33(2):141-147.