Details of the Drug

General Information of Drug (ID: DMQFPI1)

Drug Name

mRNA-3927

Indication

Disease Entry	ICD 11	Status	REF
Propionic acidemia	5C50.E0	Phase 2	[1]
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Drug Type

mRNA therapy

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Propionyl-CoA carboxylase alpha chain, mitochondrial messenger RNA (PCCA mRNA)	TT1JDE3	PCCA_HUMAN	Not Available	[2]
Propionyl-CoA carboxylase beta chain, mitochondrial messenger RNA (PCCB mRNA)	TT5LURU	PCCB_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05130437) A Phase 1/2, Global, Open-Label, Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study. U.S.National Institutes of Health.
2	Translational Pharmacokinetic/Pharmacodynamic Model for mRNA-3927, an Investigational Therapeutic for the Treatment of Propionic Acidemia. Nucleic Acid Ther. 2023 Apr;33(2):141-147.