General Information of Drug (ID: DMQNRGE)

Drug Name
PTG-100 Drug Info
Indication
Disease Entry ICD 11 Status REF
Ulcerative colitis DD71 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMQNRGE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Integrin beta-7 (ITGB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vedolizmab DMV3YMX Crohn disease DD70 Approved [2]
Rhumab Beta7 DMGOTK4 Ulcerative colitis DD71 Phase 3 [3]
AMG-181 DMODJTX Crohn disease DD70 Phase 2 [4]
Drug(s) Targeting Integrin alpha-4 (ITGA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vedolizmab DMV3YMX Crohn disease DD70 Approved [2]
Antegren DMNC64R Multiple sclerosis 8A40 Approved [5]
Natalizumab DMAK85L Crohn disease DD70 Approved [6]
PB006 DMVHGLA Crohn disease DD70 Phase 3 [7]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [8]
AMG-181 DMODJTX Crohn disease DD70 Phase 2 [1]
Senktide DMOH8LD Epilepsy 8A60-8A68 Phase 2 [9]
BIO-1211 DMKICA3 Asthma CA23 Phase 2 [10]
ELND-002 DMM9S51 Autoimmune diabetes 5A10 Phase 1 [11]
ELND-004 DMLQYVD Autoimmune diabetes 5A10 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-4 (ITGA4) TT4BT06 ITA4_HUMAN Antagonist [1]
Integrin beta-7 (ITGB7) TTLT9XQ ITB7_HUMAN Antagonist [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of Takeda (2009).
3 A randomised phase I study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis. Gut. 2013 Aug;62(8):1122-30.
4 Pharmacology of AMG 181, a human anti-alpha4 beta7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol. 2013 May;169(1):51-68.
5 Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curr Opin Chem Biol. 1998 Aug;2(4):453-7.
6 Natalizumab in Multiple Sclerosis Treatment: From Biological Effects to Immune Monitoring. Front Immunol. 2020 Sep 24;11:549842.
7 Efficacy and Safety of Proposed Biosimilar Natalizumab (PB006) in Patients With Relapsing-Remitting Multiple Sclerosis: The Antelope Phase 3 Randomized Clinical Trial. JAMA Neurol. 2023 Mar 1;80(3):298-307.
8 Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):603-11.
11 Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15;170(12):5912-8.