Details of the Drug

General Information of Drug (ID: DMODJTX)

Drug Name
AMG-181
Synonyms Inflammatory bowel disease therapeutics, Amgen
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 2 [1]
Ulcerative colitis DD71 Phase 2 [2]
Drug Type
Antibody
Cross-matching ID
TTD ID
D04WQJ
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-4 (ITGA4) TT4BT06 ITA4_HUMAN Inhibitor [2]
Integrin beta-7 (ITGB7) TTLT9XQ ITB7_HUMAN Not Available [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01696396) AMG 181 in Subjects With Moderate to Severe Crohn's Disease. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Pharmacology of AMG 181, a human anti-alpha4 beta7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol. 2013 May;169(1):51-68.