Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQSMB1)

Drug Name

GS-9160 Drug Info

Synonyms

GS-9160; GS9160; N-[7-(4-Fluorobenzyl)-9-Hydroxy-8-Oxo-7,8-Dihydro-6h-Pyrrolo[3,4-G]quinolin-5-Yl]-N-Methylmethanesulfonamide; N-(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl)-N-methylmethanesulfonamide; SCHEMBL4652222; CHEMBL513189; RJWBOLLTMJMYNV-UHFFFAOYSA-N; ZINC35078403; GS 9160; 915407-80-6; ZZV; N-[7-[(4-fluorophenyl)methyl]-9-hydroxy-8-oxo-6H-pyrrolo[3,4-g]quinolin-5-yl]-N-methyl-methanesulfonamide; Methanesulfonamide, N-(7-((4-fluorophenyl)methyl)-7,8-dihydro-9-hydroxy-8-oxo-6H

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Terminated	[1]

Cross-matching ID

PubChem CID: 16097721
CAS Number: CAS 915407-80-6
TTD Drug ID: DMQSMB1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Integrase (HIV IN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[2]
Raltegravir	DMYURI6	Human immunodeficiency virus infection	1C62	Approved	[3]
Elvitegravir	DMG9B1U	Human immunodeficiency virus infection	1C62	Approved	[2]
Bictegravir, emtricitabine and tenofovir alafenamide	DMG0H8K	Human immunodeficiency virus infection	1C62	Approved	[4]
GSK1265744	DMT8J0I	Human immunodeficiency virus infection	1C62	Phase 3	[5]
S-1360	DM9KTSG	Human immunodeficiency virus infection	1C62	Phase 2	[6]
S-364735	DMU7ZMH	Human immunodeficiency virus infection	1C62	Phase 2	[7]
C-2507	DMOFT1V	Human immunodeficiency virus infection	1C62	Phase 1	[8]
Acriflavine	DMKVE8X	Human immunodeficiency virus infection	1C62	Phase 1	[9]
S-265744 LAP	DMDQRWT	Human immunodeficiency virus infection	1C62	Phase 1	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Integrase (HIV IN)	TT5FH9Y	POL_HV1B1	Inhibitor	[1]

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References

1	Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother. 2009 Mar;53(3):1194-203.
2	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
3	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
4	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	HIV-1 integrase inhibitors: an emerging clinical reality. Drugs R D. 2007;8(3):155-68.
7	The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8.
8	Elvitegravir: a new HIV integrase inhibitor. Antivir Chem Chemother. 2009 Oct 19;20(2):79-85.
9	Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment. Biomed Pharmacother. 1999 Dec;53(10):484-6.
10	Long-acting shot prevents infection with HIV analogue. Nature. doi:10.1038/nature.2014.14819. 04 March 2014