Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQSO4L)

Drug Name

ML-04 Drug Info

Synonyms

BTL-cg; HP-4; ML-04A; Urological therapeutics, Milkhaus; Human chorionic gonadotropin (benign prostate hyperplasia/prostatitis/cancer), Beech Tree Labs

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMQSO4L

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Luteinizing hormone receptor (LHCGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chorionic Gonadotropin	DMFT73E	Fertility disorders	5A61	Approved	[3]
Choriogonadotropin alfa	DMFMZ3G	Female infertility	GA31.Z	Approved	[3]
Lutropin alfa	DM7K5GD	Female infertility	GA31.Z	Approved	[4]
Org-43902	DME0WX2	Infertility	GB04	Phase 1	[5]
LDI-200	DMKMTR7	leukaemia	2A60-2B33	Discontinued in Phase 3	[6]
Human chorionic gonadotropin	DMA7EFM	Heart disease	BA41-BA42	Terminated	[6]
EP-200	DMAURX5	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00044226) A 20-Week Study of a New Treatment for Men With Benign Prostatic Hyperplasia (BPH).. U.S. National Institutes of Health.
2	Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol. 2007 Jan;34(1):55-70.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Lutropin alfa. Drugs. 2008;68(11):1529-40.
5	First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254).