General Information of Drug (ID: DMQU8AR)

Drug Name
Org-20599 Drug Info
Synonyms Org-20549
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Terminated [1]
Cross-matching ID
PubChem CID
9850026
CAS Number
CAS 156685-94-8
TTD Drug ID
DMQU8AR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [3]
Gaboxadol DMI53FU Insomnia 7A00-7A0Z Approved [4]
Ganaxolone DMXJMKF Epileptic seizures 8A61-8A6Z Approved [5]
SAGE-217b DMRFK0B Major depressive disorder 6A70.3 Phase 2 [3]
PF-4480682 DMWYJHC Neuropathic pain 8E43.0 Discontinued in Phase 2 [6]
PF-2393296 DM5R2MG Neuropathic pain 8E43.0 Discontinued in Phase 1 [7]
Co-60549 DMGIZHX Anxiety disorder 6B00-6B0Z Terminated [8]
TBPS DMFC3XP Discovery agent N.A. Investigative [7]
RU-5135 DMCASRD Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor delta (GABRD) TTGXH6N GBRD_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003651)
2 The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22.
3 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4 Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6.
5 Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Ann Neurol. 1998 Oct;44(4):688-91.
6 WO patent application no. 2014,1515,17, Methods of improving microvascular integrity.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 416).
8 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007012)
9 Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 1;227(2):147-51.