Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQXI9F)

• Drug Name: L-Phenylalanine Drug Info
• Synonyms: Endophenyl; Fenilalanina; Phe; Phenylalanine; Phenylalaninum; Fenilalanina [Spanish]; Phenylalaninum [Latin]; Antibiotic FN 1636; CB 3208; NCI9959; Alpha-Aminohydrocinnamic acid; Beta-Phenylalanine; L-Antibiotic FN 1636; L-PHENYLALININE; N-Formylmelphalan; Phenylalanine (VAN); H-Phe-OH; L-Phenylalanine (JP15); Phenylalanine (USP/INN); Phenylalanine [USAN:INN:JAN]; Beta-Phenyl-L-alanine; N-Formyl-L-sarcolysin; N-Formyl-L-p-sarcolysin; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); (2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Malnutrition	5B50-5B71	Approved	[1] , [2]

• Therapeutic Class: Dietary supplement
• Cross-matching ID:
  PubChem CID: 6140
  ChEBI ID: CHEBI:17295
  CAS Number: CAS 63-91-2
  TTD Drug ID: DMQXI9F
  VARIDT Drug ID: DR00266
  INTEDE Drug ID: DR2108

Molecule-Related Drug Atlas

Drug(s) Transported By L-type amino acid transporter 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-valine	DM68RPD	Discovery agent	N.A.	Investigative	[6]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[6]
L-isoleucine	DM4B6H3	Discovery agent	N.A.	Investigative	[6]

Drug(s) Transported By L-type amino acid transporter 4 (SLC43A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-valine	DM68RPD	Discovery agent	N.A.	Investigative	[7]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[7]
L-isoleucine	DM4B6H3	Discovery agent	N.A.	Investigative	[7]

Drug(s) Transported By L-type amino acid transporter 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[10]
Glycine	DMIOZ29	Malnutrition	5B50-5B71	Approved	[10]
L-alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[10]
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[10]
L-tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[10]

Drug(s) Targeting Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[4]
Tetrahydrobiopterin	DMINZ4W	Malnutrition	5B50-5B71	Approved	[11]
Metyrosine	DMBYCU0	Pheochromocytoma	5A75	Approved	[12]
L1-79	DMLHPVW	Autism spectrum disorder	6A02	Phase 2	[13]
ProSavin	DMJ42E6	Parkinson disease	8A00.0	Phase 1/2	[14]
OXB-102	DMXF9DM	Parkinson disease	8A00.0	Phase 1/2	[15]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[16]
alpha-propyldopacetamide	DMQKMX3	Discovery agent	N.A.	Investigative	[17]
Meta-Tyrosine	DM0748C	Discovery agent	N.A.	Investigative	[16]
3-iodotyrosine	DMNZMH6	Discovery agent	N.A.	Investigative	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosine 3-monooxygenase (TH)	TTUHP71	TY3H_HUMAN	Binder	[3] , [4] , [5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
L-type amino acid transporter 3 (SLC43A1)	DTBMSWG	LAT3_HUMAN	Substrate	[6]
L-type amino acid transporter 4 (SLC43A2)	DTK02I1	LAT4_HUMAN	Substrate	[7]
L-type amino acid transporter 2 (SLC7A8)	DTJF3DX	LAT2_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Phenylalanine--tRNA ligase mitochondrial (FARS2) Main DME	DE0WGR8	SYFM_HUMAN	Substrate	[9]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3313).
• [2] Drug information of L-Alanine, Health Canada, 2008. (drugid: 1025)
• [3] Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67.
• [4] Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5.
• [5] In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes. Biochem Biophys Res Commun. 2003 Feb 7;301(2):610-6.
• [6] Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.
• [7] Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.
• [8] Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628.
• [9] Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. J Mol Biol. 1999 May 14;288(4):567-77.
• [10] The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
• [11] Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20.
• [12] Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8.
• [13] Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981.
• [14] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [15] Clinical pipeline report, company report or official report of Oxford BioMedica.
• [16] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243).