Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR0EWV)

Drug Name

SAR342434 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 3	[1]
Type-1 diabetes	5A10	Phase 3	[2]
Type-2 diabetes	5A11	Phase 3	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inulin	DM1Y2JH	Measure kidney function	MG02	Approved	[4]
Insulin Zinc Susp Recombinant Human	DM6MO9X	Diabetic complication	5A2Y	Approved	[4]
Insulin-glargine	DMR4HIW	Diabetic complication	5A2Y	Approved	[4]
Insulin Susp Isophane Recombinant Human	DMW8KI7	Diabetic complication	5A2Y	Approved	[4]
Insulin determir	DM79NZ5	Diabetic complication	5A2Y	Approved	[5]
Insulin Susp Protamine Zinc Beef/Pork	DM0NATE	Diabetic complication	5A2Y	Approved	[4]
Insulin-aspart	DMX7V28	Diabetic complication	5A2Y	Approved	[4]
Insulin degludec	DMPL395	Type-1/2 diabetes	5A10-5A11	Approved	[6]
Insulin-detemir	DMOA4VW	Type-1/2 diabetes	5A10-5A11	Approved	[4]
LY2963016	DMEZ0H5	Type-1/2 diabetes	5A10-5A11	Phase 3	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT02273180) Comparison of SAR342434 to Humalog as the Rapid Acting Insulin in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Biosimilar insulins: a European perspective. Diabetes Obes Metab. 2015 May; 17(5): 445-451.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
6	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
7	Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus ) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study. Diabetes Obes Metab.2015 Aug;17(8):726-33.