Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR1NYF)

Drug Name

KH064 Drug Info

Synonyms

sPLA2-2A inhibitor, compound 2b

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Clinical trial	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Group IIA phospholipase A2 (GIIA sPLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[2]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[2]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[3]
2-(4-phenoxyphenoxy)ethanamine	DM7TBUJ	Discovery agent	N.A.	Investigative	[4]
CACOSPONGIONOLIDE	DMIPJUS	Discovery agent	N.A.	Investigative	[5]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[2]
Cacospongionolide E	DM2DYAV	Discovery agent	N.A.	Investigative	[5]
N-Tridecanoic Acid	DMNZ37C	Discovery agent	N.A.	Investigative	[3]
CACOSPONGIONOLIDE B	DMCSXNW	Discovery agent	N.A.	Investigative	[5]
BOLINAQUINONE	DMVB6UG	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Group IIA phospholipase A2 (GIIA sPLA2)	TTO8QRU	PA2GA_HUMAN	Inhibitor	[1]

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References

1	D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.
5	A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.
6	New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.