General Information of Drug (ID: DMR6USG)

Drug Name
PELITREXOL Drug Info
Synonyms AG-2037; Pelitrexol < USAN; AG-2032 (racemate); AG-2038 ((6R)-isomer); N-[5-[2-[2-Amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6(S)-yl]ethyl]-4-methylthien-2-ylcarbonyl]-L-glutamic acid
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
PubChem CID
135431074
CAS Number
CAS 446022-33-9
TTD Drug ID
DMR6USG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY309887 DMJPCHK Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
10-Formyl-5,8,10-Trideazafolic Acid DMEBHML Discovery agent N.A. Investigative [4]
Glycinamide Ribonucleotide DMW180Y Discovery agent N.A. Investigative [4]
(10r)-10-Formyl-5,8,10-Trideazafolic Acid DMVTLF9 Discovery agent N.A. Investigative [4]
10-trifluoroacetyl-DDACTHF DMEAGI6 Discovery agent N.A. Investigative [5]
Dideazaacyclotetrahydrofolic acid DM9WU3R Discovery agent N.A. Investigative [6]
10-CF3C(OH)2-DDACTHF DMQOUJ7 Discovery agent N.A. Investigative [4]
Dideazafolate DMAIOC9 Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycinamide ribonucleotide formyltransferase (GART) TTEXB9Z PUR2_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00078468) Study of the GARFT Inhibitor AG2037 in Patients With Metastatic Colorectal Cancer Who Failed Treatment. U.S. National Institutes of Health.
2 Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors. J Clin Oncol (Meeting Abstracts) July 2004 vol. 22 no. 14_suppl 3075.
3 New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer. 1998;78 Suppl 3:1-7.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002.
6 Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8.
7 N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 1987 Jul;30(7):1254-6.