Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRBYH8)

Drug Name

Sepimostat mesylate Drug Info

Synonyms

Renofuthan; FUT-187; TO-187

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Serine protease unspecific (SP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[3]
Gabexate	DMU9D2F	Pancreatitis	DC31-DC34	Approved	[3]
Aprotinin	DM0QD4W	Bleeding disorder	GA20-GA21	Approved	[4]
Sivelestat sodium hydrate	DMOSJD0	Acute lung injury	NB32.3	Phase 4	[5]
Camostat	DMQ7UL8	Cystic fibrosis	CA25	Phase 2	[6]
VT-111a	DMY9ZGN	Acute coronary syndrome	BA41	Phase 2	[7]
VT-111	DMOY15R	Graft rejection in heart transplantation	NE84	Preclinical	[8]
NPI-1999	DMH1YL8	Thrombosis	DB61-GB90	Terminated	[9]
SDZ-MTH-958	DMKCXBJ	Artery stenosis	BD52	Terminated	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine protease unspecific (SP)	TTEMV5X	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002018)
2	Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant. Gan To Kagaku Ryoho. 1996 Dec;23(14):1971-9.
3	Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20.
4	Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding Clin Trials. 2005;2(3):218-29; discussion 229-32.
5	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
6	Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9.
7	Viral Serpin Therapeutics: From Concept to Clinic. Methods Enzymol. 2011; 499: 301-329.
8	New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
9	US patent application no. 2005,0096,323, Diketopiperazine derivatives to inhibit thrombin.
10	Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27;61(6):862-8.