General Information of Drug (ID: DMRKYD6)

Drug Name
2-acetyl-3-hydroxycyclohex-2-enone Drug Info
Synonyms
CHEMBL73025; 37514-00-4; SCHEMBL5628771; CTK1B5605; DTXSID50472617; YKOOMGHHVDVJAY-UHFFFAOYSA-N; 2-Acetyl-3-hydroxy-cyclohex-2-enone; 2-Acetyl-3-hydroxy-2-cyclohexen-1-one; 2-Cyclohexen-1-one, 2-acetyl-3-hydroxy-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11788412
CAS Number
CAS 37514-00-4
TTD Drug ID
DMRKYD6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitisinone DMVS9WQ Hereditary tyrosinemia type 1 5C50.11 Approved [2]
BMS-433771 DME20VP Respiratory syncytial virus infection 1C80 Terminated [3]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [4]
2-(2-Nitro-benzoyl)-cyclohexane-1,3-dione DMUJQX1 Discovery agent N.A. Investigative [5]
2-(2-Iodo-benzoyl)-cyclohexane-1,3-dione DMSVHU9 Discovery agent N.A. Investigative [5]
2-(2-Bromo-benzoyl)-cyclohexane-1,3-dione DM3VH7F Discovery agent N.A. Investigative [5]
Diketonitrile DMPKQER Discovery agent N.A. Investigative [6]
2-(2-Methoxy-benzoyl)-cyclohexane-1,3-dione DMESMBO Discovery agent N.A. Investigative [5]
3-Hydroxy-4-phenyl-5H-furan-2-one DM5QZDL Discovery agent N.A. Investigative [7]
(4-Hydroxy-phenoxy)-acetic acid DMRCM5O Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hydroxyphenylpyruvate dioxygenase (HPD) TT8DSFC HPPD_HUMAN Inhibitor [1]

References

1 Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl deri... Bioorg Med Chem Lett. 2006 Dec 1;16(23):6024-7.
2 Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36.
3 Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5.
6 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6.
7 Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1709-13.