Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRML9B)

Drug Name
Isoxazoles and isoxazoline derivative 1 Drug Info
Synonyms PMID27172114-Compound-82
Cross-matching ID
TTD Drug ID
DMRML9B

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Kynurenine 3-hydroxylase (KMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK065 DMO87YS Pancreatitis DC31-DC34 Phase 1 [2]
Isoxazoles and isoxazoline derivative 2 DMKCYSD N. A. N. A. Patented [1]
Aryl pyrimidine derivative 7 DM8FAW3 N. A. N. A. Patented [1]
Aryl pyrimidine derivative 2 DMU9Y4B N. A. N. A. Patented [1]
Cyclopropane 1-carboxylic acid derivative 6 DM0OMBW N. A. N. A. Patented [1]
PMID27172114-Compound-47 DMTIQYD N. A. N. A. Patented [1]
Isoxazoles and isoxazoline derivative 4 DMW3JZV N. A. N. A. Patented [1]
Cyclopropane 1-carboxylic acid derivative 2 DMSXB58 N. A. N. A. Patented [1]
Cyclopropane 1-carboxylic acid derivative 9 DMLH9AQ N. A. N. A. Patented [1]
Cyclopropane 1-carboxylic acid derivative 10 DM3M169 N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kynurenine 3-hydroxylase (KMO) TTIY56R KMO_HUMAN Inhibitor [1]

References

1 Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.
2 Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.