Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRXW9P)

Drug Name

GSK-2130579A Drug Info

Synonyms

Leukemia vaccine, GlaxoSmithKline; WT1 ASCI, GlaxoSmithKline; WT1 antigen specific cancer immunotherapeutic, GlaxoSmithKline; WT1 vaccine, GlaxoSmithKline

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMRXW9P

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Wilms tumor protein (WT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Combined PR1/WT1 vaccine	DMGCTX5	Myeloid leukaemia	2B33.1	Phase 2	[3]
WT1 peptide vaccine	DMZ67Q0	leukaemia	2A60-2B33	Phase 2	[4]
WT1-targeted autologous dendritic cell vaccine	DMNFZYE	Acute myeloid leukaemia	2A60	Phase 2	[5]
FPI-01	DMXOTMP	Acute myeloid leukaemia	2A60	Phase 2	[6]
WT-4869	DM3FIMD	leukaemia	2A60-2B33	Phase 1/2	[7]
INNO-305	DMG6S8U	Acute myeloid leukaemia	2A60	Phase 1	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Wilms tumor protein (WT1)	TTZ8UT4	WT1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT01051063) Evaluation of a New Anti-cancer Immunotherapy in Adult Acute Myeloid Leukemia Patients With a Suboptimal Clinical Response to Induction Chemotherapy. U.S. National Institutes of Health.
2	Spoilight on personalized medicine. A pharma matters report, Thomson Reuters, 2012.
3	Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42.
4	Wilms' tumor protein 1 (WT1) peptide vaccination in AML patients: predominant TCR CDR3beta sequence associated with remission in one patient is detectable in other vaccinated patients. Cancer ImmunolImmunother. 2012 Mar;61(3):313-22.
5	ClinicalTrials.gov (NCT01686334) Efficacy Study of Dendritic Cell Vaccination in Patients With Acute Myeloid Leukemia in Remission. U.S. National Institutes of Health.
6	Clinical pipeline report, company report or official report of Formula Pharmaceuticals.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033385)
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023753)