Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRZJU5)

Drug Name

2,6-dimethyl-8-ethyl-1-deazapurine Drug Info

Synonyms

133240-06-9; 2-Ethyl-5,7-dimethyl-1H-imidazo[4,5-b]pyridine; 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine; CHEMBL221579; 3H-Imidazo[4,5-b]pyridine,2-ethyl-5,7-dimethyl-; 5,7-Dimethyl-2-ethylimidazo[4,5-b]pyridine; 3H-Imidazo[4,5-b]pyridine, 2-ethyl-5,7-dimethyl-; 2,6-dimethyl-8-ethyl-1-deazapurine; ACMC-20dzbe; SCHEMBL1918476; CTK4B8431; DTXSID40431137; XWWJWZJOSWSJQV-UHFFFAOYSA-N; ZINC22058897; BDBM50205288; ANW-72022; AKOS000278272; AKOS015904384; RTX-011778; FCH1411209; AM803160; SC-21701; KB-23752; AJ-80864; TC-160767

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9815374
CAS Number: CAS 133240-06-9
TTD Drug ID: DMRZJU5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Adenosine A1 receptor (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[2]
Rolofylline	DMSZPR3	Heart failure	BD10-BD13	Phase 3	[3]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[4]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[5]
SELODENOSON	DMQM3IX	Cardiac arrhythmias	BC9Z	Phase 2	[6]
Apaxifylline	DMQMV9F	Cognitive impairment	6D71	Phase 2	[7]
SLV320	DM867BJ	Heart failure	BD10-BD13	Phase 2	[8]
DTI-0009	DMV84OK	Atrial fibrillation	BC81.3	Phase 2	[6]
Capadenoson	DMYWO62	Atrial fibrillation	BC81.3	Phase 2	[9]
BAY 1067197	DM4JGNH	Heart failure	BD10-BD13	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A1 receptor (ADORA1)	TTK25J1	AA1R_HUMAN	Inhibitor	[1]

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References

1	2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34.
2	Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.
3	Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009 Aug 17;117(7):265-72.
4	2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203.
5	Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53.
6	Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)
8	Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart. Clin Sci (Lond). 2009 Jul 16;117(4):157-64.
9	A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10.
10	Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Current Issue vol. 111 no. 12 Celine Valant, 4614-4619.