Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS2WV3)

Drug Name

AIDSVAX Drug Info

Synonyms

AIDSVAX B/B; AIDSVAX B/E; Bivalent gp120 HIV vaccines, GSID; Bivalent gp120 HIV vaccines, Global Solutions for Infectious Diseases; Bivalent gp120 HIV vaccines, VaxGen

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 3	[1]

Cross-matching ID

TTD Drug ID: DMS2WV3

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fostemsavir	DM50ILT	Human immunodeficiency virus infection	1C62	Approved	[3]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[4]
BMS-488043	DMRPU10	Human immunodeficiency virus infection	1C62	Discontinued in Phase 2	[5]
Pro 542	DMLOGR3	Human immunodeficiency virus infection	1C62	Discontinued in Phase 2	[6]
PF-821385	DMNZG8T	Human immunodeficiency virus infection	1C62	Preclinical	[7]
CD4 red blood cell electroinsertion	DMIV82T	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120)	TTBYP1X	ENV_HV1H2	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00006327) Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand. U.S. National Institutes of Health.
2	HIV gp120 vaccine - VaxGen: AIDSVAX, AIDSVAX B/B, AIDSVAX B/E, HIV gp120 vaccine - Genentech, HIV gp120 vaccine AIDSVAX - VaxGen, HIV vaccine AIDSVAX - VaxGen. Drugs R D. 2003;4(4):249-53.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2020
4	An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.
5	The investigations on HIV-1 gp120 bound with BMS-488043 by using docking and molecular dynamics simulations.J Mol Model.2013 Feb;19(2):905-17.
6	Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother. 2004 Feb;48(2):423-9.
7	Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution. PLoS Pathog. 2013 February; 9(2): e1003184.
8	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120. J Acquir Immune Defic Syndr. 1990;3(11):1041-5.