General Information of Drug (ID: DMS9EKG)

Drug Name
VCL-1M01 Drug Info
Synonyms
VCL-IM01; EPT (plasmid DNA), Vical; IL-2/EP; MedPulser, cancer (plasmid DNA), Vical; Plasmid DNA (transdermal, EPT), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma); IL-2 gene therapy (pVCL-1102 plasmid DNA vector, melanoma), Vical; IL-2 gene therapy (plasmid, transdermal, melanoma), Vical
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMS9EKG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldesleukin DM4YMIS Acute myelogenous leukaemia 2A41 Approved [3]
Daclizumab DM6OZQV Aplastic anemia 3A70 Approved [4]
AIR-insulin DM8SYTE Diabetic complication 5A2Y Phase 3 [5]
TG-4010 DMWE3GB Bipolar disorder 6A60 Phase 2/3 [6]
BNZ-1 DM8JQZC Cutaneous T-cell lymphoma 2B01 Phase 2 [7]
IL-2/CD40L-expressing leukemia vaccine DMIHQ5G Chronic lymphocytic leukaemia 2A82.0 Phase 2 [8]
Carboxyamidotriazole orotate DMN5JCX Glioblastoma multiforme 2A00.0 Phase 2 [9]
Leuvectin DM5LQEI Melanoma 2C30 Phase 2 [10]
Human interleukin-2 DM0NJWG Renal cell carcinoma 2C90 Phase 2 [11]
L19-IL-2 fusion protein DMI2XP1 Lymphoma 2A80-2A86 Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-2 (IL2) TTF89GD IL2_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT00223899) A Trial to Evaluate the Safety of Intratumoral VCL-IM01 Followed by Electroporation in Metastatic Melanoma. U.S. National Institutes of Health.
2 Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther. 1995 Mar;2(2):164-7.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
5 The AIR inhaled insulin system: system components and pharmacokinetic/glucodynamic data. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S41-7.
6 A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44.
7 Clinical pipeline report, company report or official report of Bioniz Therapeutics.
8 Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and a... Blood. 2006 Feb 15;107(4):1332-41.
9 J Clin Oncol 32:5s, 2014 (suppl; abstr 2071).
10 Intratumoral interleukin 2 for renal-cell carcinoma by direct gene transfer of a plasmid DNA/DMRIE/DOPE lipid complex. World J Urol. 2000 Apr;18(2):152-6.
11 Clinical pipeline report, company report or official report of Immunservice.
12 National Cancer Institute Drug Dictionary (drug id 665656).