Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSA8RU)

• Drug Name: Abatacept Drug Info
• Synonyms: Orencia (TN)

Indication

Disease Entry	ICD 11	Status	REF
Alopecia areata	ED70.2	Approved	[1]
Crohn disease	DD70	Approved	[2]
Multiple sclerosis	8A40	Approved	[3]
Rheumatoid arthritis	FA20	Approved	[4]
Systemic lupus erythematosus	4A40.0	Approved	[5]

• Therapeutic Class: Antirheumatic Agents
• Cross-matching ID: TTD Drug ID: DMSA8RU

Molecule-Related Drug Atlas

Drug(s) Targeting T-lymphocyte activation antigen CD86 (FUN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MAXY-4	DMMP7XG	Autoimmune diabetes	5A10	Phase 1	[7]
Tolerimab	DMZKIE0	Transplant rejection	NE84	Terminated	[8]

Drug(s) Targeting Activation B7-1 antigen (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RhuDex	DMGM1IR	Rheumatoid arthritis	FA20	Phase 2a	[9]
HS-110	DML4RCG	Non-small-cell lung cancer	2C25.Y	Phase 2	[10]
Galiximab	DMTXCUS	Lymphoma	2A80-2A86	Phase 2	[11]
MAXY-4	DMMP7XG	Autoimmune diabetes	5A10	Phase 1	[7]
CAR-T cells targeting CD80/86	DM6Z7AD	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
Tolerimab	DMZKIE0	Transplant rejection	NE84	Terminated	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Activation B7-1 antigen (CD80)	TTFZDNP	CD80_HUMAN	Binder	[6]
T-lymphocyte activation antigen CD86 (FUN1)	TTHGXBU	CD86_HUMAN	Binder	[6]

References

• [1] Alopecia Areata: a Comprehensive Review of Pathogenesis and Management. Clin Rev Allergy Immunol. 2018 Feb;54(1):68-87.
• [2] Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007 May 12;369(9573):1641-57.
• [3] Advances in immune checkpoint-based immunotherapies for multiple sclerosis: rationale and practice. Cell Commun Signal. 2023 Nov 9;21(1):321.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6891).
• [5] Systemic Lupus Erythematosus Management in Pregnancy. Int J Womens Health. 2022 Feb 15;14:199-211.
• [6] Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2009 May-Jun;27(3):510-8.
• [7] Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.
• [8] US patent application no. 2004,0171,123, Albumin fusion proteins.
• [9] A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
• [10] Clinical pipeline report, company report or official report of Heat Biologics.
• [11] Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma. J Clin Oncol. 2005 Jul 1;23(19):4390-8.
• [12] ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers