Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSCV02)

Drug Name

[N-methyl-3H(3)]AZ-10419369 Drug Info

Synonyms

AR-A2; AZ-01134; AZ-10419369; AZ-12320927; AZ-12333053; AZ-12426308; AZ-12426792; AZD-8129; M-519351; M-549715; M-555601; AR-A-000002; AR-A2 analogs, AstraZeneca

Indication

Disease Entry	ICD 11	Status	REF
Mood disorder	6A60-6E23	Phase 1	[1] , [2]

Cross-matching ID

PubChem CID: 25067576
TTD Drug ID: DMSCV02

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting 5-HT 1B receptor (HTR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[5]
Eletriptan	DMW649X	Migraine	8A80	Approved	[6]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[6]
Frovatriptan	DM7RE8P	Migraine	8A80	Approved	[6]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[6]
Naratriptan	DMO50U2	Migraine	8A80	Approved	[7]
Prolixin decanoate	DMMJ1IS	Schizophrenia	6A20	Approved	[6]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[8]
NXN-188	DMMBAIH	Migraine	8A80	Phase 2	[9]
Alniditan	DMFE3CT	Migraine	8A80	Discontinued in Phase 3	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1B receptor (HTR1B)	TTK8CXU	5HT1B_HUMAN	Antagonist	[3] , [4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3219).
2	ClinicalTrials.gov (NCT01085123) Determine Central 5-HT1B Receptor Occupancy of ZOMIG Rapimelt (Zolmitriptan) in Healthy Male Volunteers. U.S. National Institutes of Health.
3	5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neurosci Lett. 2015 May 6;594:137-43.
4	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.
5	Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7	Triptans in pregnancy. Ther Drug Monit. 2008 Feb;30(1):5-9.
8	Clinical pipeline report, company report or official report of Jazz Pharmaceuticals.
9	Company report (NeurAxon)
10	Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65.