Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSK5N3)

Drug Name
SR8278 Drug Info
Synonyms SR 8278; SR-8278
Indication
Disease Entry ICD 11 Status REF
Myocardial disease BC43.20 Preclinical [1]
Cross-matching ID
PubChem CID
53393127
CAS Number
CAS 1254944-66-5
TTD Drug ID
DMSK5N3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting V-erbA-related protein 1 (NR1D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK4112 DM1S5UO Inflammation 1A00-CA43.1 Preclinical [2]
SR9009 DM8SKU1 Solid tumour/cancer 2A00-2F9Z Preclinical [3]
SR9011 DMZ9BO8 Solid tumour/cancer 2A00-2F9Z Preclinical [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
V-erbA-related protein 1 (NR1D1) TTAD1O8 NR1D1_HUMAN Antagonist [2]

References

1 Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
2 Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6(2):131-4.
3 Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018 Jan 18;553(7688):351-355.