Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSKCEH)

• Drug Name: PMID25468267-Compound-46 Drug Info
• Cross-matching ID:
  PubChem CID: 53392492
  TTD Drug ID: DMSKCEH

Molecule-Related Drug Atlas

Drug(s) Targeting Lysine-specific demethylase 4E (KDM4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyqunoline analog 1	DMAJFDT	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 2	DMWSZMC	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 2	DMX3TZ7	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 7	DM13K8R	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 4	DMGPCSR	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 5	DM5QAKR	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 9	DMTMYJ6	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 2	DMCNWPI	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 5	DM673GR	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 4	DMUE7R5	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Lysine-specific demethylase 4A (KDM4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-(2-phenylcyclopropyl) amino acid derivative 1	DMH7T8C	N. A.	N. A.	Patented	[2]
Heteroaryl-cyclopropylamine derivative 4	DMMU01R	N. A.	N. A.	Patented	[2]
PMID27019002-Compound-21b	DMMC31N	N. A.	N. A.	Patented	[2]
Hydroxamate analog 1	DMGATHZ	N. A.	N. A.	Patented	[1]
PMID27019002-Compound-21c	DMWZOKP	N. A.	N. A.	Patented	[2]
Disulfiram analog 1	DMOEFD3	N. A.	N. A.	Patented	[1]
Selenium compound 2	DMLWIJ7	N. A.	N. A.	Patented	[1]
Disulfiram analog 2	DMOMGU5	N. A.	N. A.	Patented	[1]
Selenium compound 1	DM9C5Z8	N. A.	N. A.	Patented	[1]
Selenium compound 3	DMQ5AJ6	N. A.	N. A.	Patented	[1]

Drug(s) Targeting Lysine-specific demethylase 4C (KDM4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxamate analog 1	DMGATHZ	N. A.	N. A.	Patented	[1]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 4	DM09FOQ	N. A.	N. A.	Patented	[1]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 1	DMF0XI3	N. A.	N. A.	Patented	[1]
PMID25468267-Compound-56	DMAI19Z	N. A.	N. A.	Patented	[1]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 5	DMO3QDW	N. A.	N. A.	Patented	[1]
PMID25468267-Compound-47	DMG2JEK	N. A.	N. A.	Patented	[1]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 7	DMXY3F0	N. A.	N. A.	Patented	[1]
Pyrido[1,2-a]indole-1.-carboxylic acid analog 3	DMCLKBY	N. A.	N. A.	Patented	[1]
Flavonoid derivative 6	DM0E38G	N. A.	N. A.	Patented	[1]
PMID25468267-Compound-55	DMIXQRY	N. A.	N. A.	Patented	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific demethylase 4A (KDM4A)	TTZHPB8	KDM4A_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 4C (KDM4C)	TTV8CRH	KDM4C_HUMAN	Inhibitor	[1]
Lysine-specific demethylase 4E (KDM4E)	TTWAQBO	KDM4E_HUMAN	Inhibitor	[1]

References

• [1] KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.
• [2] LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.