Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSKI8W)

Drug Name

KPG-121 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cerebron E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KPG-818	DM1O2X6	Systemic lupus erythematosus	4A40.0	Phase 1	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cerebron E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase)	TTEZQ39	CUL4A_HUMAN/CUL4B_HUMAN-DDB1_HUMAN-CRBN_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT03569280) Evaluation of Safety and Efficacy of KPG-121 Plus Enzalutamide, Abiraterone or Apalutamide in CRPC Patients. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Kangpu Biopharmaceuticals.