Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSP4JX)

Drug Name

Cetraxate Drug Info

Synonyms

Neuer; NeuerCap; NeuerS; Cetraxate hydrochloride; DV-1006

Indication

Disease Entry	ICD 11	Status	REF
Peptic ulcer	DA61	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Kallikrein-related peptidase (KLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bortezomib	DMNO38U	Leukemia		Approved	[3]
Ecallantide	DMOF2C6	Retina venous occlusion	9B74.1	Approved	[4]
LM-030	DMSJOE3	Congenital ichthyosiform erythroderma	EC20.02	Phase 2	[5]
Benzoxazinone derivative 2	DM4FHTG	N. A.	N. A.	Patented	[6]
Benzyl amine derivative 1	DMOU84B	N. A.	N. A.	Patented	[6]
Benzyl amine derivative 2	DMFK7EL	N. A.	N. A.	Patented	[6]
Heteroaryl-carboxamide derivative 11	DM1CWU7	N. A.	N. A.	Patented	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kallikrein-related peptidase (KLK)	TT5L2VC	NOUNIPROTAC	Modulator	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	A new broad spectrum inhibitor of esteroproteases, 4-(2-carboxyethyl) phenyl-trans-4-aminomethyl cyclohexane carboxylate hydrochloride (DV 1006). Tohoku J Exp Med. 1972 Mar;106(3):233-48.
3	Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22.
4	Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110.