Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSPBOW)

• Drug Name: AIC100 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Thyroid cancer	2D10	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMSPBOW

Molecule-Related Drug Atlas

Drug(s) Targeting Intercellular adhesion molecule ICAM-1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
lifitegrast	DM4WVC5	Dry eye disease	9E1Z	Approved	[3]
Alicaforsen	DMQ509J	Lleum inflammation	1A40.0	Phase 3	[4]
BI-505	DMSZQHX	Multiple myeloma	2A83	Phase 2	[5]
APC-8015F	DM3VP19	Prostate cancer	2C82.0	Phase 2	[6]
GI-270384X	DM3KN2Q	Inflammatory bowel disease	DD72	Terminated	[7]
A-252444.0	DMDTA36	Inflammation	1A00-CA43.1	Terminated	[8]
MOR-102	DMRCH1M	Psoriasis vulgaris	EA90	Terminated	[9]
ISIS-1939	DMGN4OQ	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intercellular adhesion molecule ICAM-1 (ICAM1)	TTCT6F7	ICAM1_HUMAN	Not Available	[2]

References

• [1] ClinicalTrials.gov (NCT04420754) Study of AIC100 in Relapsed/Refractory Thyroid Cancer. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of AffyImmune Therapeutics.
• [3] Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013 Apr 15;23(4):502-15.
• [6] National Cancer Institute Drug Dictionary (drug id 561410).
• [7] Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96.
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566)
• [9] Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005 Oct;153(4):758-66.
• [10] Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem. 1991 Sep 25;266(27):18162-71.